five.17 Bone-Marrow Despair Promethazine HCl and codeine phosphate oral Resolution ought to be used with caution in clients with bone-marrow despair. Leukopenia and agranulocytosis have already been reported, ordinarily when promethazine continues to be Utilized in Affiliation with other acknowledged marrow-harmful brokers.
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Existence-threatening respiratory despair and Loss of life have occurred in children who gained codeine; most instances adopted tonsillectomy and/or adenoidectomy, and lots of of the kids experienced evidence of currently being an extremely-speedy metabolizer of codeine due to a CYP2D6 polymorphism. (5.3) Promethazine HCl and codeine phosphate oral Alternative is contraindicated in youngsters young than twelve many years of age and in little ones younger than 18 several years of age next tonsillectomy and/or adenoidectomy.
Reproductive toxicity experiments haven't been conducted with promethazine HCl and codeine phosphate oral Answer; even so, reports can be obtained with particular person Energetic elements (see Knowledge).
Promethazine HCl and codeine phosphate oral Answer must be applied with warning in people with impairment of hepatic purpose, and people should be monitored closely for respiratory despair, sedation, and hypotension.
Hazard Summary Promethazine HCl and codeine phosphate oral solution isn't suggested for use in Expecting Women of all ages, together with during or instantly prior to labor.
To lower your threat, your health practitioner should have you take the smallest dose that works, and choose it for your shortest attainable time. See also The best way to Use part for more information about addiction.
Lean will get its identify in the influence it's got on individuals who consume it: they tend to slouch or lean to one aspect the more they eat the substance. The results of codeine are like All those of other addictive opioids (like oxycodone and heroin).
Prevent the usage of promethazine HCl and codeine phosphate oral Resolution in sufferers using muscle mass relaxants. If concomitant use is essential, observe people for signs of respiratory depression Which might be larger than normally anticipated.
If you’re a mother or father who is battling to overcome the psychological, psychological, or physical tension of your son or daughter working with lean or other illicit medicine, on the net therapy can be quite a excellent location to get started on.
five.19 Neonatal Opioid Withdrawal Syndrome Promethazine HCl and codeine phosphate oral solution is not recommended to be used in pregnant Females. Prolonged use of promethazine HCl and codeine phosphate oral Remedy for the duration of pregnancy may lead to withdrawal from the neonate. Neonatal opioid withdrawal syndrome, unlike opioid withdrawal syndrome in Older people, may very well be life-threatening if not recognized and dealt with, and necessitates administration according to protocols designed by neonatology industry experts.
The euphoric emotion that cocaine produces plus the brief size of the superior normally bring about consumers to work with A lot more. For inexperienced consumers, who may have not formulated a tolerance into the drug, this may lead to overdose and Dying.
Promethazine and codeine mix is made use of To alleviate cough, runny or stuffy nose, sneezing, or other signs attributable to allergies or perhaps the frequent cold.
Existence-Threatening Respiratory Depression Advise sufferers of the risk of life-threatening respiratory here melancholy, which includes facts that the danger is finest when beginning promethazine HCl and codeine phosphate oral Option and that it might occur even at proposed dosages [see Warnings and Safeguards (five.